Anti-TNBC agent-2 [CAS 2422001-22-5]

Anti-TNBC agent-2 (3j) an anti-Triple negative breast cancer (TNBC) purine derivative. anti-TNBC agent-2 induces MDA-MB-231 cells apoptosis, and inhibits its migration and angiogenesis. anti-TNBC agent-2 inhibits tumor growth and metastasis and reduces the expression of Ki67 and CD31 protein in TNBC xenograft models. anti-TNBC agent-2 can be used for Triple negative breast cancer (TNBC) research[1].

[2422001-22-5]

C28H37ClFN7O

542.09

FC1=CC=C(C=C1Cl)CNC2=C3N=CN(C3=NC(N4CCC(CC4)C5CCN(CC5)CCO)=N2)CC6CC6

Apoptosis; DNA/RNA Synthesis

10 mM in DMSO

Room temperature