Antibacterial agent 119

Antibacterial agent 119 (Compound 21 g) is an antibacterial candidate against Methicillin -resistant Staphylococcus aureus (MICs less than 1 μg/mL against tested strains). Antibacterial agent 119 induces ROS production. Antibacterial agent 119 also acts on the bacterial cell membrane to cause membrane breakage. Antibacterial agent 119 exhibits potent antibacterial activity with low cytotoxicity, rapid bactericidal ability, and good in vivo antibacterial activity[1].

C42H54BrClN2O4

766.25

C[C@@]12[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](CCC5=[N+](CC6=CC=C(Cl)C=C6)C=CC7=C5NC8=C7C=C(OC)C=C8)C)([H])C[C@H](O)CC1.[Br-]

Bacterial; Reactive Oxygen Species (ROS)

Room temperature