Antibacterial agent 297

Antibacterial agent 297 (Compound A40), an antibacterial agent, is a Lsrk inhibitor (IC50: 0.40 μM; KD: 3.79 μM) . Antibacterial agent 297 inhibits biofilm formation and bacterial motility and changes biofilm morphology through AI-2 QS inhibition rather than direct antibacterial effects. Antibacterial agent 297 has favorable oral PK properties[1].

C21H21BrN2O3

429.31

BrC1=CC=C(C=C1)CCC(NC2=CC3=C(N(CCCC(O)=O)C=C3)C=C2)=O

Bacterial

Room temperature