Anticonvulsant agent 5 [CAS 9007-83-4]

Anticonvulsant agent 5 (Compound 5c) exhibits high affinity for GABAA receptors and NaV1.3 receptors. Anticonvulsant agent 5 shows anticonvulsant efficacy in mice psychomotor epilepsy test with an ED50 of 107 mg/kg. Anticonvulsant agent 5 exhibits neuroprotective activity against Kainic acid with an IC50 of 113 μM. Anticonvulsant agent 5 is blood-brain barrier (BBB) penetrable[1].

[9007-83-4]

C24H21FN4O2S

448.51

S=C1N(C2=CC=C(OC)C=C2)C(C(NC(C3=CC=C(F)C=C3)=O)CC4=CC=CC=C4)=NN1

GABA Receptor; Sodium Channel

Room temperature