Antidepressant agent 9 [CAS 143899-90-5]

Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test[1].

[143899-90-5]

C17H24N2

256.39

CN1[C@]2([H])[C@]3([H])[C@@](CC1)(CCCC3)C4=CC(N)=CC=C4C2

IGluR; Serotonin Transporter

Room temperature