Antifungal agent 31 [CAS 2077083-94-2]

Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections[1].

[2077083-94-2]

C25H22F2N6O3

492.48

O=C1N([C@H](C)[C@@](O)(C2=CC=C(F)C=C2F)CN3N=CN=C3)N=CC4=CC(C5=CC=C(OC)C=C5)=CN14

Fungal

10 mM in DMSO

Room temperature