Antileishmanial agent-21 [CAS 9007-83-4]

Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine -resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM[1].

[9007-83-4]

C21H16N2O3

344.36

OC(C(OC)=C1)=CC=C1C(C2=C(C3=CC=CC=C3CC2)NC4=O)=C4C#N

Parasite

10 mM in DMSO

Room temperature