Antimalarial agent 18 [CAS 9007-83-4]

Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM) [1].

[9007-83-4]

C23H44NO9P

509.57

CCCCCCCC(OCOP(CCCC(N(O)C)=O)(OCOC(CCCCCCC)=O)=O)=O

Parasite

Plasmodium

10 mM in DMSO

Room temperature