Antimalarial agent 41 [CAS 9007-83-4]

Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain) . Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models[1].

[9007-83-4]

C19H18F3N5

373.37

FC(C1=CC=C(C2=CC=C3N=CC=C(NC4CCNCC4)C3=N2)C=N1)(F)F

PI4K; Potassium Channel

PI4K

Room temperature