Antiparasitic agent-15 [CAS 9007-83-4]

Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes[1].

[9007-83-4]

C17H16N4OS

324.4

CC1(S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C

Necroptosis; Parasite

Trypanosoma

10 mM in DMSO

Room temperature