AP-7-168 [CAS 2816062-15-2]

AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR) . AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma[1].

[2816062-15-2]

C20H19BrF2N4

433.29

FC1=C(C=C(C=C1)NC2=NC3=CC=C(C=C3C(NC4CCCCC4)=N2)Br)F

Adrenergic Receptor; Molecular Glues

β adrenergic receptor

Room temperature