AP 811 (acetate)

AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation[1][2].

C46H66N12O8.xC2H4O2

NC(NCCC[C@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC(CC(C=C1)=CC=C1NC(C2=CC3=C(C=C2)C=CC=C3)=O)=O)CCCNC(N)=N)=O)[C@@H](C)CC)=O)=O)C(NC[C@@H](C)CC)=O)=N.CC(O)=O.[x]

Endothelin Receptor

10 mM in DMSO

Room temperature