Apelin-17 (human, bovine) (TFA)

Apelin-17 (human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17 (human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02) . Apelin-17 (human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

C98H157F3N34O22S

2252.57

OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCCCN)C(NCC(N4[C@@H](CCC4)C(N[C@@H](CCSC)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Apelin Receptor (APJ) ; HIV

HIV-1; HIV-2

10 mM in DMSO

Room temperature