APKC-IN-2 [CAS 15854-08-7]
APKC-IN-2 [CAS 15854-08-7]
SKU:QM-0119232-01
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Product Details
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Description
APKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors[1].
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CAS Number
[15854-08-7]
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Molecular Formula
C14H15NO2S
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Molecular Weight
261.34
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Smiles
O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC
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Target
Endogenous Metabolite
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Purity
99.8
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Solubility
DMSO : 62.5 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Hazard Statement
H315, H319, H335
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Precautions
H315, H319, H335
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APKC-IN-2 [CAS 15854-08-7]
APKC-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.