APN-PEG4-DBCO

APN-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. APN-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

C39H40N4O7

676.76

O=C(CCC(NCCOCCOCCOCCOCCC(NC1=CC=C(C#CC#N)C=C1)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

ADC Linker

Cleavable Linker

10 mM in DMSO

Room temperature