ARD-2051 [CAS 2632305-17-8]

ARD-2051 is a selective and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 exhibits effective anti-tumor activity in VCaP xenograft mice model. ARD-2051 can be used for the research of prostate cancer (Pink: AR ligand , Blue: CRBN Ligand (HY-14658), Black: Linker).

[2632305-17-8]

C43H45ClN8O5

789.32

O=C(C1=C2C=CC(N3CC(N4CCN(C(C5=CC=C(C=C5)N6CCC7(CC6)CN([C@H](C7)C)C8=CC(Cl)=C(C=C8)C#N)=O)CC4)C3)=C1)N(C2=O)C9C(NC(CC9)=O)=O

Androgen Receptor; PROTACs

Cereblon

98.57

DMSO : 25 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature