ARI-1

ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38. ARI-1 induces Apoptosis. ARI-1 has anticancer activity against non-small cell lung cancer[1].

C20H22O7

374.38

O=C1C[C@H](C2=CC=C(OC)C=C2)OC3=C1C(OCOC)=CC(OCOC)=C3

Akt; Apoptosis; mTOR; PARP; ROR

99.16

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature