AS-254s

AS-254s is the inhibitor for absent, small, or homeotic-like 1 protein (ASH1L) with an IC50 of 94 nM (FP assay) . AS-254s exhibits antiproliferative activity against MLL1-rearranged leukemic cells with GI50 [1].

C36H41ClN6O3S2

705.33

ClC1=C(C2=CC=C1CNC(C3CC4(C3)CCN(CC4)CCNC(C5=NC=CS5)=O)=O)N(C=C2C6=CC(C(N)=S)=CC=C6)C7CCOCC7

Histone Methyltransferase

98.96

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature