Name: AS2863619 [CAS 2241300-51-4]
Brand: QuantiMol
SKU: QM-0142001-01
Price: 257.76 GBP
Availability: InStock

Product Details

Description
AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].
CAS Number
[2241300-51-4]
Molecular Formula
C16H14Cl2N8O
Molecular Weight
405.24
Smiles
NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5.[H]Cl.[H]Cl
Target
CDK; STAT
Isoform
CDK19; CDK8; GSK-3α; GSK-3β; STAT5
Purity
98.02
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Shipping Conditions
Room Temperature

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Variant	Variant total	Quantity	Price	Variant total
1 mgQM-0142001-01	1 mgQM-0142001-01 £257.76/ea	£0.00	Quantity	£257.76/ea	£0.00

5 mgQM-0142001-02	5 mgQM-0142001-02 £489.83/ea	£0.00	Quantity	£489.83/ea	£0.00

10 mM - 1 mLQM-0142001-03	10 mM - 1 mLQM-0142001-03 £533.57/ea	£0.00	Quantity	£533.57/ea	£0.00

10 mgQM-0142001-04	10 mgQM-0142001-04 £740.12/ea	£0.00	Quantity	£740.12/ea	£0.00

50 mgQM-0142001-05	50 mgQM-0142001-05 £2,121.57/ea	£0.00	Quantity	£2,121.57/ea	£0.00

100 mgQM-0142001-06	100 mgQM-0142001-06 £2,873.66/ea	£0.00	Quantity	£2,873.66/ea	£0.00

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AS2863619 [CAS 2241300-51-4]

AS2863619 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.