ASF-006 (sodium)

ASF-006 sodium, a tetrapodal tryptophan derivative, is a potent viral invasion inhibitor. ASF-006 sodium shows potent antiviral activity against different SARS-CoV-2 Omicron variants but not against the ancestral SARS-CoV.2 strain (Wuhan-Hu-1) . ASF-006 sodium competitively inhibits receptor-binding domain (RBD) -ACE2 binding via an allosteric mechanism. ASF-006 sodium inhibits Omicron BA.1, Omicron XBB.1.5, respiratory syncytial virus (RSV) and Ebola virus infection with IC50s of 0.02 μM, 0.3 μM, 1.52 μM and 0.2 μM, respectively. ASF-006 sodium inhibits cell entry of both HIV and enterovirus A71[1].

C125H80N8Na20O48

2921.79

O=C(C(CC1=C(C2=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C2)NC3=C1C=CC=C3C4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)NC(CCOCC(COCCC(NC(C(O[Na])=O)CC(C5=C(N6)C(C7=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C7)=CC=C5)=C6C8=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C8)=O)(COCCC(NC(CC9=C(C%10=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%10)NC%11=C9C=CC=C%11C%12=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%12)C(O[Na])=O)=O)COCCC(NC(CC%13=C(C%14=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%14)NC%15=C%13C=CC=C%15C%16=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%16)C(O[Na])=O)=O)=O)O[Na]

Angiotensin-converting Enzyme (ACE) ; Enterovirus; Filovirus; HIV; RSV; SARS-CoV

Room temperature