Aspulvinone O [CAS 914071-54-8]

Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models[1][2].

[914071-54-8]

C27H28O6

448.51

OC1=C(C2=CC(C/C=C(C)/C)=C(O)C=C2O)C(O/C1=C/C3=CC(C/C=C(C)/C)=C(O)C=C3)=O

Aminotransferases (Transaminases) ; Apoptosis

GOT/AST

96

DMSO : 25 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice