Asundexian-d3 [CAS 2975248-62-3]

Asundexian-d3 (BAY-2433334-d3) is the deuterium labeled Asundexian. Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].

[2975248-62-3]

C26H18D3ClF4N6O4

595.95

ClC1=CC(C(C(OC([2H])([2H])[2H])=CN2[C@@H](CC)C(NC3=CC(F)=C(C=C3)C(N)=O)=O)=CC2=O)=C(N4C=C(N=N4)C(F)(F)F)C=C1

Factor Xa; Isotope-Labeled Compounds

Room temperature