ATM-IN-2

ATM-IN-2 is a selective and orally active ATM inhibitor with an IC50 of 4 nM. ATM-IN-2 exhibits excellent kinase selectivity (>700-fold over PIKK family members) . ATM-IN-2 exerts its anti-tumor effect by inhibiting ATM phosphorylation and the downstream signaling pathways (p53, H2AX), and promotes cell apoptosis. ATM-IN-2 can be used for the study of chemosensitizer candidate such as colon cancer[1].

C25H21N3O3S

443.52

CC(S(=O)(C1=CC=C(C=C1)C2=CN=C3NC=C(C3=C2)C4=CC(C5=CC=CC=C5)=NO4)=O)C

Apoptosis; ATM/ATR

ATM

Room temperature