ATR-IN-6 [CAS 2746446-99-9]

ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22) [1].

[2746446-99-9]

C28H28FN7O2

513.57

OCC1=CC(C2=NC(N3[C@@H](COCC3)C)=CC(C4=C(N(C5=CN=CC(F)=C5)N=C4C)C)=N2)=C6C(NC=C6)=C1

ATM/ATR

10 mM in DMSO

Room temperature