ATX-IN-1

ATX-IN-1 (compound 35) is an inhibitor of ATX (IC50=0.7 nM) with anti-inflammatory activity. ATX-IN-1 can inhibit TGF-β/Smad pathway and reduce collagen deposition to alleviate Bleomycin -induced fibrosis in mice. ATX-IN-1 has good oral bioavailability (F=69.5%) and particle stability[1].

C25H22N6O5

486.48

O=C1N(CCC2=C1N(C3=CN(COC)N=C3)N=C2C(NC4=CC=CC=C4C(O)=O)=O)C5=CC=CC=C5

Phosphodiesterase (PDE)

Room temperature