AURKA-IN-3

AURKA-IN-3 (Compound AL8) is an irreversible covalent Aurora kinase A (AURKA) inhibitor with an IC50 value of 23.0 nM. AURKA-IN-3 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by AURKA, and reduces the autophosphorylation level of AURKA. AURKA-IN-3 is promising for research of malignant tumors associated with high AURKA expression (e.g., leukemia, lymphoma) [1].

C38H28ClFN6O6

719.12

O=C(NC1=CC=C(NC2=C(OC)C(C2=O)=O)C=C1)C3=CC=C(NC4=NC=C5C(C6=CC=C(Cl)C=C6C(C7=C(OC)C=CC=C7F)=NC5)=N4)C=C3OC

Aurora Kinase

Aurora A

Room temperature