AUTAC1 [CAS 2241669-09-8]

AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC) . AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1].

[2241669-09-8]

C44H63FN8O11S

931.08

CO[C@H]1[C@@]([C@]([C@H]2C/C=C(C)\C)(O2)C)([H])[C@@]3(CO3)CC[C@H]1OC(NCCCOCCOCCOCCCNC([C@@H](NC(C)=O)CSC4=NC5=C(N=C(N)NC5=O)N4CC6=CC=C(F)C=C6)=O)=O

AUTACs; Autophagy

95

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature