Avitinib [CAS 1557267-42-1]

Avitinib (Abivertinib) is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib shows anticancer effects[1][2].

[1557267-42-1]

C26H26FN7O2

487.53

O=C(C=C)NC1=CC=CC(OC2=NC(NC3=CC(F)=C(N4CCN(C)CC4)C=C3)=NC5=C2C=CN5)=C1

Apoptosis; Btk; EGFR

EGFR/ErbB1/HER1

99.95

DMSO : 83.33 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335