AVN-101 [CAS 1025725-91-0]

AVN-101 is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively) . AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis[1].

[1025725-91-0]

C21H24N2

304.43

CC1=CC2=C(N(CCC3=CC=CC=C3)C4=C2CN(C)CC4)C=C1

5-HT Receptor; Adrenergic Receptor; Histamine Receptor

5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor

Room temperature