AX-53802 [CAS 1008482-71-0]

AX-53802 is a ferroptosis inducer targeting GPX4 with an IC50 of 0.34 µM. AX-53802 forms a covalent bond with GPX4, initiating membrane translocation directly upon binding. AX-53802 and FAK/Src inhibitors promotes cell death. AX-53802 can be used for cancer study[1].

[1008482-71-0]

C23H21FN2O4

408.42

O=C(NC1CCCC1)C(C2=C(F)C=CC=C2)N(C(C#C)=O)C3=CC=C4C(OCO4)=C3

Ferroptosis; Glutathione Peroxidase

GPX4

Room temperature