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AXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1
SKU:QM-0009579
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Product Details
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Description
AXL/Angiokinase-IN-1 (compound 11b) is an AXL/triple angiokinase inhibitor, IC50=3.75 nM (AXL expression) . AXL/Angiokinase-IN-1 inhibits epithelial-mesenchymal transition (EMT) in Bxpc-3, blocking lung cancer cell metastasis. AXL/Angiokinase-IN-1 also inhibits vascular and fibroblast functions, promoting apoptosis (apoptosis) in cancer cells and fibroblasts. AXL/Angiokinase-IN-1 features low toxicity and good metabolic stability[1].
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Molecular Formula
C31H34ClN5O2
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Molecular Weight
544.09
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Smiles
O=C1NC2=CC(Cl)=CC=C2/C1=C(C3=CC=CC=C3)/NC4=CC=C(C=C4)N(C)C(C(C)N5CCN(CC5)CC)=O
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Target
Apoptosis; FGFR; PDGFR; VEGFR
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Shipping Conditions
Room temperature
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AXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.