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SKU:QM-0146498-01
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AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2].
[1835734-92-3]
C21H32N4O4
404.5
O=C(N)[C@H](C1CCCCC1)NC([C@H](CC2CCCCC2)NC(C3=CC=NO3)=O)=O
Protease Activated Receptor (PAR)
PAR2
10 mM in DMSO
Room temperature
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AY77 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.