AZ-5104-d2 [CAS 2719691-01-5]

AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively[1].

[2719691-01-5]

C27H29D2N7O2

487.59

O=C(NC1=CC(NC2=NC=CC(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCN(C)C)/C=C([2H])\[2H]

EGFR

10 mM in DMSO

Room temperature