AZ13824374 [CAS 3040082-19-4]

AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells) . AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1].

[3040082-19-4]

C30H39FN8O2

562.68

O=C1N[C@H](C(C)C)[C@H]2C3=CC=CC=C3C[C@@H]1N2C(C4=NN5C(C(NC6CCN(CC(C)(F)C)CC6)=C4)=NN=C5C)=O

Epigenetic Reader Domain

10mM

99.22

DMSO : ≥ 200 mg/mL

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature