AZD 9272 is a selective, orally active and brain penetrant mGluR5 antagonist with IC50s of 2.6 nM and 7.6 nM for rat and human receptors, respectively. AZD 9272 shows >3900-fold selectivity over other mGlu receptors[1]2].
CAS Number
[327056-26-8]
Molecular Formula
C14H6F2N4O
Molecular Weight
284.22
Smiles
N#CC1=CC(F)=CC(C2=NC(C3=CC=C(F)C=N3)=NO2)=C1
Target
MGluR
Isoform
MGluR5
Purity
99.87
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)