Azido-PEG8-Amido-Val-Cit-PAB [CAS 2356229-77-9]

Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

[2356229-77-9]

C40H69N9O15

916.03

[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(COCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O)=O

ADC Linker

Room temperature