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B-Raf IN 9 [CAS 2477725-18-9]
B-Raf IN 9 [CAS 2477725-18-9]
SKU:QM-0067631
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Product Details
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Description
B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].
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CAS Number
[2477725-18-9]
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Molecular Formula
C23H20N4OS
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Molecular Weight
400.5
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Smiles
S=C(NC1=CC=CC=C1)NC2=CC=C(C(CC3)=NN(C4=CC=CC=C4)C3=O)C=C2
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Target
Apoptosis; Raf
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Isoform
B-Raf
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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B-Raf IN 9 [CAS 2477725-18-9]
B-Raf IN 9 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.