Balixafortide (TFA)

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s [1][2].

C86H119F3N24O23S2

1978.16

O=C(C(F)(F)F)O.O=C1[C@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@]4([H])N(CCC4)C([C@@H](NC([C@@H](NC([C@@](CSSC3)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]5([H])N1CCC5)=O)CC6=CC=C(C=C6)O)=O)CC7=CN=CN7)=O)C)=O)=O)CO)=O)C)=O)=O)CCN)=O)CCCNC(N)=N)=O)CC8=CC=C(C=C8)O)=O)=O)CC9=CC=C(C=C9)O)=O)CCC(N)=O)=O)CCCCN)=O

Arrestin; CXCR

CXCR4

99.89

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Blue Ice