Bardoxolone methyl [CAS 218600-53-4]
Bardoxolone methyl [CAS 218600-53-4]
SKU:QM-0076040-01
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Product Details
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Description
Bardoxolone (CDDO; RTA 401) methyl is an orally active and brain-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) [1][2][3][4][5].
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CAS Number
[218600-53-4]
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Molecular Formula
C32H43NO4
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Molecular Weight
505.69
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Smiles
O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(OC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C
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Target
Keap1-Nrf2; SARS-CoV; Virus Protease
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Purity
99.66
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Bardoxolone methyl [CAS 218600-53-4]
Bardoxolone methyl is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.