BAY-8040 [CAS 1194453-23-0]

BAY-8040 is a pyrimidopyridazine derivative which has inhibitory activity against human neutrophil elastase (HNE). BAY-8040 decreases cardiac remodeling and ameliorates cardiac function in a Monocrotaline -induced rat model for pulmonary arterial hypertension. BAY-8040 is promising for research of inflammatory pathologies and cardiopulmonary pathologies[1][2].

[1194453-23-0]

C21H16F3N5O2

427.38

N#CC1=CC=C([C@H](C2=C3CN(C)NC2=O)NC(N3C4=CC=CC(C(F)(F)F)=C4)=O)C=C1

Elastase

Room temperature