BC-1293 [CAS 1219395-86-4]

BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice[1].

[1219395-86-4]

C26H28N4O4S

492.59

O=S(C1=CC(C2=NOC(C3CC3)=N2)=CC=C1C)(NC(C(N4CCC(C5=CC=CC=C5)=CC4)=O)C)=O

E1/E2/E3 Enzyme

Room temperature