BC13 [CAS 3036645-03-8]

BC13 is a CDK6/BRD4 inhibitor with the IC50 values of 234 nM and 36 nM for CDK6 and BRD4, respectively. BC13 shows antiproliferative activity and induces cell apoptosis and DNA damage. BC13 increases in ROS levels[1].

[3036645-03-8]

C37H39N7O5

661.75

COC1=C2C(NC(C3=CC=C(C=C3)C(N4CC5(C4)CCN(CC5)C6=NC(N7C8CCCC8)=C(C=N6)C(C)=CC7=O)=O)=NC2=CC(OC)=C1)=O

Apoptosis; CDK; DNA/RNA Synthesis; Epigenetic Reader Domain; Reactive Oxygen Species (ROS)

Room temperature