BChE-IN-39

BChE-IN-39 (Compound 7c) is a selective inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.08 μM (IC50=3.98 μM for AChE) . BChE-IN-39 downregulates the GSK-3β expression, inhibits the hyperphosphorylation of tau protein[1].

C29H23ClFN3O3

515.96

FC1=CC(C[N+]2=CC=CC(CNC(C3=CC=C(CN(C(C4=C5C=CC=C4)=O)C5=O)C=C3)=O)=C2)=CC=C1.[Cl-]

Cholinesterase (ChE)

AChE; BChE

Room temperature