BCR-ABL-IN-10

BCR-ABL-IN-10 (compound B4) is a covalent and aryl vinyl sulfate (AVS) -containing BCR-ABL inhibitor with an IC50 of 43.1 nM for ABL kinase. BCR-ABL-IN-10 forms a covalent and stable adduct with ABL kinase, leading to sustained inhibition of endogenous BCR-ABL activities. BCR-ABL-IN-10 can be used for the study of chronic myeloid leukemia (CML) [1].

C24H22N4O5S

478.52

COC(C(C1=CNC2=NC=C(C=C12)C3=CC(C(N(C)C)=O)=CN=C3)=C4)=CC=C4OS(C=C)(=O)=O

Bcr-Abl

Room temperature