Benidipine [CAS 105979-17-7]

Benidipine is a potent and orally active calcium channel antagonist[1]. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells[2]. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats[3].

[105979-17-7]

C28H31N3O6

505.56

O=C(C1=C(C)NC(C)=C(C(O[C@H]2CN(CC3=CC=CC=C3)CCC2)=O)[C@@H]1C4=CC=CC([N+]([O-])=O)=C4)OC

Apoptosis; Calcium Channel

L-type calcium channel

10 mM in DMSO

Room temperature

H301

P264-P270-P330-P405-P501