BET BD2-IN-1 [CAS 2677039-24-4]

BET BD2-IN-1 (compound 45) is a potent and selective inhibitor of BET BD2 (IC50=1.6 nM) . BET BD2-IN-1 inhibits the differentiation of Th17 cells by decreasing the activation of STAT3 and NF-κB. BET BD2-IN-1 is used in psoriasis and inflammatory bowel disease (IBD) research[1].

[2677039-24-4]

C30H30N4O2

478.58

O=C(C1=CC=CC(CN2C3=C(C=C4C5=C2C=CC=C5C(N4C)=O)C=CC=C3)=C1)NC6CCN(CC6)C

Epigenetic Reader Domain

BRD2; BRD3; BRD4; BRDT

10 mM in DMSO

Room temperature