BET-IN-28

BET-IN-28 (Compound 44) is a highly potent inhibitor of bromodomain and extra-terminal domain (BET), with an IC50 value of 4.47 nM against BRD4-BD1. BET-IN-28 blocks the interaction between BET proteins and N-acetylated lysine residues on histone tails, down-regulates certain genes. BET-IN-28 can be used for hematological malignancies and solid tumors study[1].

C26H29N9O2

499.57

OCCNC1=NN=C2C(N([C@@H](C3=NC=CC=C3)C4CCOCC4)C5=C2C=CC(C6=C(C)N=NN6C)=C5)=N1

Epigenetic Reader Domain

Room temperature