Bethanidine (sulfate) [CAS 114-85-2]
Bethanidine (sulfate) [CAS 114-85-2]
SKU:QM-0106565
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Product Details
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Description
Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects[1].
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CAS Number
[114-85-2]
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Molecular Formula
C10H17N3O4S
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Molecular Weight
275.32
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Smiles
O=S(O)(O)=O.CN/C(NC)=N/CC1=CC=CC=C1.[0.5]
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Target
Adrenergic Receptor
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Shipping Conditions
Room temperature
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Bethanidine (sulfate) [CAS 114-85-2]
Bethanidine (sulfate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.