Bfl-1-IN-2

Bfl-1-IN-2 (Compound 13) is a reversible and covalent inhibitor of Bfl-1 (IC50: 4.3 μM) . Bfl-1-IN-2 acts by binding to Cys55 of Bfl-1[1].

C23H22F3N2O2P

446.4

O=C(NCC1(C2=CC=C(C(F)(F)F)C=C2)CC1)/C(C#N)=C/C3=CC=CC=C3P(C)(C)=O

Bcl-2 Family

Bfl-1

99.76

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature