Bfl-1-IN-6

Bfl-1-IN-6 (Compound 20) is an orally active inhibitor for Bcl-2 related protein A1 (BFL1) with an IC50 of 19 nM. Bfl-1-IN-6 stabilizes BFL1 protein, activates cleaved caspase 3, and exhibits antitumor efficacy in mouse models[1].

C22H24ClFN2O2

402.89

O=C(N([C@@H](C)C1=CC=C(Cl)C=C1)C2=CC(F)=C(O[C@@H]3CC[C@@H](N)C3)C=C2)C=C

Bcl-2 Family; Caspase

Room temperature